Press Releases
Osivax Announces Publication in The Lancet Infectious Diseases of Phase 2a Data for Broad-Spectrum Influenza Vaccine Candidate, OVX836
Osivax Announces Publication in The Lancet Infectious Diseases of Phase 2a Data for Broad-Spectrum Influenza Vaccine Candidate, OVX836 OVX836 demonstrated positive safety …
Osivax Publishes Preclinical Data for Sarbecovirus Vaccine Candidate, OVX033 in Frontiers in Immunology
Osivax Publishes Preclinical Data for Sarbecovirus Vaccine Candidate, OVX033in Frontiers in Immunology Evidence of cross-protection against multiple SARS-CoV-2 variants of concern observed …
Osivax Announces Vaccination of First Participant in Phase 2a Clinical Trial Evaluating OVX836 Combined with QIVs
Osivax Announces Vaccination of First Participant in Phase 2a Clinical Trial Evaluating OVX836 Combined with QIVs Australia-based Phase 2a clinical study to …
Media Coverage
Publications
Immunogenicity, safety, and preliminary efficacy evaluation of OVX836, a nucleoprotein-based universal influenza A vaccine candidate: a randomised, double-blind, placebo-controlled, phase 2a trial.
Leroux-Roels I et al.
THE LANCET Infectious Diseases, Jul. 2023. doi: 10.1016/S1473-3099(23)00351-1
Randomized, Double-Blind, Reference-Controlled, Phase 2a Study Evaluating the Immunogenicity and Safety of OVX836, A Nucleoprotein-Based Influenza Vaccine.
Leroux-Roels I et al.
Frontiers in Immunology, Apr. 2022. doi: 10.3389/fimmu.2022.852904
Phase 1 Randomized, Placebo-Controlled, Dose-Escalating Study to Evaluate OVX836, a Nucleoprotein-Based Influenza Vaccine: Intramuscular Results.
Withanage K et al.
The Journal of Infectious Diseases, Oct. 2021. doi: 10.1093/infdis/jiab532
OVX836 Heptameric Nucleoprotein Vaccine Generates Lung Tissue-Resident Memory CD8+ T-Cells for Cross-Protection Against Influenza.
Del Campo J et al.
Frontiers in Immunology, Jun. 2021. doi: 10.3389/fimmu.2021.678483
OVX836 a recombinant nucleoprotein vaccine inducing cellular responses and protective efficacy against multiple influenza A subtypes.
Del Campo J et al.
Nature partner journals, Jan. 2019. doi: 10.1038/s41541-019-0098-4.
OVX033, a nucleocapsid-based vaccine candidate provides broad-spectrum protection against SARS-CoV-2 variants in a hamster challenge model
Primard C et al.
Frontiers in Immunology, Jun. 2023. doi: 10.3389/fimmu.2023.1188605
Combined prophylactic and therapeutic immune responses against human papillomaviruses induced by a thioredoxin-based L2-E7 nanoparticle vaccine.
Zhao X et al.
PLoS Pathogens, 2020 Sep. 16(9):e1008827. doi: 10.1371/journal.ppat.1008827
Minor capsid protein L2 polytope induces broad protection against oncogenic and mucosal human papillomaviruses.
Pouyanfard S et al.
Journal of Virology, 2018 Feb. 92:e01930-17. doi: 10.1128/JVI.01930-17.
Broadly neutralizing antiviral responses induced by a single-molecule HPV vaccine based on thermostable thioredoxin-L2 multiepitope nanoparticles.
Spagnoli G et al.
Scientific Reports, 2017 Dec. 7: 18000. doi: 10.1038/s41598-017-18177-1.
SnoopLigase peptide-peptide conjugation enables modular vaccine assembly
Andersson AC et al.
Scientific Reports, Mar. 2019. 15;9(1):4625. doi: 10.1038/s41598-019-40985-w.
Combination of RTS,S and Pfs25-IMX313 Induces a Functional Antibody Response Against Malaria Infection and Transmission in Mice.
Brod F et al.
Frontiers in Immunology, Dec. 2018. 4;9:2780. doi: 10.3389/fimmu.2018.02780.
Dual Plug-and-Display Synthetic Assembly Using Orthogonal Reactive Proteins for Twin Antigen Immunization.
Brune KD et al.
Bioconjugate Chemistry, May 2017. 17;28(5):1544-1551. doi: 10.1021/acs.bioconjchem.7b00174.
A HIV-Tat/C4-binding protein chimera encoded by a DNA vaccine is highly immunogenic and contains acute EcoHIV infection in mice.
Tomusange K et al.
Scientif Reports, Jun. 2016. 30;6:29131. doi: 10.1038/srep29131.
Enhancing immunogenicity and transmission-blocking activity of malaria vaccines by fusing Pfs25 to IMX313 multimerization technology.
Li Y et al.
Scientific Reports, Jan. 2016. 8;6:18848. doi: 10.1038/srep18848.
T Cell Responses Induced by Adenoviral Vectored Vaccines Can Be Adjuvanted by Fusion of Antigen to the Oligomerization Domain of C4b-Binding Protein.
Forbes EK et al.
PLoS ONE, Sep. 2012. 7(9):e44943. doi:10.1371/journal.pone.0044943.
Fusion of the Mycobacterium tuberculosis antigen 85A to an oligomerization domain enhances its immunogenicity in both mice and non-human primates.
Spencer AJ et al.
PLoS ONE, Mar. 2012. 7(3): e33555. doi:10.1371/journal.pone.0033555.
Immunocontraception in male feral swine treated with a recombinant gonadotropin-releasing hormone vaccine.
Campbell TA,et al.
Journal of Swine Health and Production, May 2010. 18(3):118-124.
The oligomerization domain of C4-binding protein (C4bp) acts as an adjuvant, and the fusion protein comprised of the 19-kilodalton merozoite surface protein 1 fused with the murine C4bp domain protects mice against malaria.
Ogun SA et al.
Infection and Immunity, Aug. 2008. 76(8):3817-3823. doi:10.1128/IAI.01369-07.
Effective induction of high-titer antibodies by viral vector vaccines.
Draper SJ et al.
Nature Medicine, Aug. 2008.14(8):819-821. doi: 10.1038/nm.1850.
Events
17th Vaccine Congress
Glasgow – Posters
Alexandre Le Vert, Chief Executive Officer and Co-founder of Osivax, to provide a clinical update on OVX836 and additional data on the cross-reactivity of the immune responses as part of two posters.
9th ESWI 2023
Valencia – Posters
Delphine Guyon-Gellin, Chief Business Development Officer of Osivax, to provide a clinical update on OVX836 as part of a poster entitled “Co-Administration of OVX836, NP-Based Universal Influenza Vaccine Candidate, with Conventional HA-Based Influenza Vaccine: Results of Phase 2a Clinical Trial”.
Florence Nicolas, Chief Development Officer and Co-founder of Osivax, to provide additional data on the cross-reactivity of the immune responses as part of a poster entitled “Cross-Reactivity of the Immune Response Triggered in a Phase 2 Study by a Novel, Broad-Spectrum Influenza Vaccine Candidate”.
World Congress Vaccine Washington 2023
Washington, DC – Oral Presentation
Alexandre Le Vert, Chief Executive Officer and Co-founder of Osivax, to provide a clinical update on OVX836 as part of a presentation entitled “Clinical Phase 2 immunogenicity results on OVX836 first-in-class broad-spectrum influenza vaccine in elderly patients”.