oligoDOMTM: A Novel
Proprietary Nanoparticles Technology specifically designed to trigger superior
T-cell responses, in addition to strong and sustained B-cell responses
The core concept
Nanoparticles self-assemble to present key immunogenic structures of a specific virus in repetition to induce an immune response.
Improving and surpassing the Nanoparticles technology
oligoDOMTM has been uniquely designed to increase the T-cell immune response to the native antigen thanks to a specific signal sequence targeting and activating cells from the immune system.
OligoDOMTM was pioneered by our co-founder, Fergal Hill, whose vision and expertise were instrumental in its development.
Building upon the established Nanoparticles concept
Given its design and mechanism of action, the oligoDOMTM technology platform is highly versatile and can be used with different antigens, as well as within different vaccine technologies such as recombinant proteins, or mRNA technology, leading to multiple value generation opportunities.
Osivax is developing several vaccine candidates, 3 of which are already in clinical phase (OVX033, OVX836 and PANHPVAX). As of today the oligoDOMTM technology has been evaluated in 7 clinical trials with more than 1,200 subjects.
Osivax is also expanding its portfolio in other areas investigating the potential synergies with other innovative vaccine technologies (like adjuvants or mRNA).
Preventing the Spread of constantly mutating Global Infectious Diseases
The innovative oligoDOMTM technology, an improved self-assembling Nanoparticles approach, targets internal and invariant parts of viruses in a very powerful way
References
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