Dr. Tim Mosmann

Dr. Tim Mosmann is Director of the human immunology center at the University of Rochester, with more than 40 years of experience and major contributions in T cell mediated immunity

• Established a high-throughput proliferation and cytotoxicity assay for cytokines
• Used this assay to show that there were discrete patterns of cytokines produced by different T cell lines. This work expanded into the characterization of different functions and further cytokine patterns of Th1 and Th2 T cells
• Demonstrated that effector T cells were specialized for different functions, and laid the groundwork for more recent demonstrations of additional stable or semi-stable T cell subsets
• Led to the prediction of a cross-regulatory cytokine, resulting in the discovery of IL-10
• Worked on a subset of uncommitted precursor T memory cells that constitute a surprisingly large proportion of many human immune responses
• Is working on the objective analysis of flow cytometry data, collaborating on the development of algorithms that allow objective mining of the rich information contained in flow cytometry datasets

Prior Experience:
• Director of the Human Immunology Center, University of Rochester, USA (1998-present)
• Professor and Chair, Department of Immunology, University of Alberta, Canada (1990-1998)
• Research Scientist, DNAX then acquired by Schering plough, Palo Alto, USA (1982-1990)
• Assistant Professor, University of Alberta (1977-1982)
• Post-doctoral fellow, University of Glasgow (1975-1977)
• Post-doctoral fellow, Hospital for Sick Children, University of Toronto (1973-1975)

• Novartis Prize for Basic Immunology, 2013
• Pillar of Immunology, 2005, 2012, 2016
• Paul Ehrlich and Ludwig Darmstaedter Prize, 2008
• ASTECH award for Outstanding Leadership in Alberta Science, 1997
• William B. Coley Award, Cancer Research Institute (USA), 1997
• Fellow of the Royal Society of Canada, 1995

• Ph.D., microbiology, University of British Columbia, Canada (1973)
• BSc, microbiology, Rhodes University, USA (1969)
• BS, Chemistry and physiology, University of Natal, South Africa (1968)